Preheat your oven to 400°F.
In a large mixing bowl, combine breadcrumbs, egg, milk, minced garlic, chili powder, onion powder, salt, black pepper, dried oregano, and red pepper flakes. Stir until well mixed.
Add the ground beef to the mixture and mix thoroughly until all ingredients are evenly distributed.
Shape the mixture into 1 1/2-inch meatballs and place them on a baking sheet lined with parchment paper, ensuring they are spaced evenly.
Bake in the preheated oven for 20 minutes or until the meatballs are cooked through and have a nice browned exterior.
Remove from the oven and let the meatballs rest for 5 minutes before serving. Serve over your favorite tomato sauce.