In a large bowl, combine ground turkey, salt, pepper, garlic powder, and Worcestershire sauce. Mix until just combined, being careful not to overwork the meat.
Form the mixture into four equal-sized patties, about 1/2 inch thick.
Preheat the air fryer to 360°F. Lightly grease the air fryer basket with cooking spray.
Place the patties in the air fryer basket, ensuring they do not touch each other for better air circulation.
Cook for 7 minutes, then flip the patties and cook for an additional 7-8 minutes, or until the internal temperature reaches 165°F.
Remove the patties from the air fryer and let them rest for a few minutes before serving.